The prophecy of a great famine spoken by the Christian prophet Agabus, and the subsequent persecution instigated by Herod Agrippa I, resulting in the apostle James’ death and the jailing of Peter, evidently took place in about 44 C.E. (Ac 11:27-30; 12:1-4) Herod Agrippa died that year,

The great fire that ravaged Rome came in July of 64 C.E. and was followed by fierce persecution of Christians, at the instigation of Nero. It is probable that Paul’s second imprisonment and his execution took place shortly thereafter. (2Ti 1:16; 4:6, 7) The exiling of John to the isle of Patmos is generally considered to have taken place during the reign of Emperor Domitian. (Re 1:9) The persecution of Christians reached a peak during his rule (81-96 C.E.), particularly in the last three years.