Mazgu Ghamusi
a Trisomy 21 ni matenda ghakubabika nagho agho ghakupangiska munthu kuŵa wakugotomara. Ico cikucitika nchakuti, maselo gha mu thupi lithu ghali na tunthu tunyake (chromosomes) uto tukuyegha DNA. Kanandi maselo agha ghakuŵa ghaŵirighaŵiri, kweni ŵana awo ŵali na trisomy 21, ŵakuŵa na maselo agha ghanandiko. Ntheura, trisomy 21 yikutimbanizga chromosomes 21.